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KMID : 0383819820290040175
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Tuberculosis and Respiratory Diseases
1982 Volume.29 No. 4 p.175 ~ p.182
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Bioavailability of Rifampicins Produced in Korea
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Kim Sang-Jae
Kim Sung-Chin
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Abstract
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A study on the quality of rifampicin produced in Korea was made by comparing with that of the reference product, rifadinR(Lepetit). Rifampicin crystals in a dosage form of local products shoved birefringency under polarizing microscope. Contamination of related compounds in local rifampicin products was not out of the accptable range, although contamination of N-oxide rifampicin exceeded 0.5% in the standard and that of reference product. Mean peak blood levels of the reference and local products in Korean men were not statistically different from one to another and they were leached at two tour after administration. More than 5.6 mcg/㎖ of rifampicin was retained in serum up to six hour post administration. Urine rifampicin levels were variable between the subjects, and the peak levels were reached at two to three hour after administration.
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